Healthcare Archives | University of Central ��ӽ紫ý News

��ӽ紫ý Scientist to Explore Precise Treatment Targeting Weak Spots in Lyme Disease Bacteria

Eddy Duryea ’13 | Photos by Eddy Duryea ’13 — Thu, 13 Aug 2026 13:30:56 +0000

Triggered by a near-painless tick bite, Lyme disease causes severe pain and inflammation for more than 475,000 people in the U.S annually, according to the Centers for Disease Control.

Medicine can treat infections after people get sick, but ��ӽ紫ý infectious disease expert Mollie Jewett is seeking to halt Borrelia burgdorferi bacteria, which causes Lyme disease, in its tracks without relying on general antibiotics. Her goal: “starve” the bacteria of the nutrients they need to function before they spread through the human body.

Jewett, professor and head of the Immunity and Pathogenesis Research Division at ��ӽ紫ý’s College of Medicine, is supported by a recently renewed five-year, $2.5 million grant from the National Institutes of Health.

��ӽ紫ý infectious disease expert Mollie Jewett.

She is entering a third consecutive federally funded research cycle with $513,314 received this year. Jewett’s research builds upon more than a decade of discoveries that have narrowed the search for ways to stop B. burgdorferi from triggering Lyme disease, one of the nation’s most common vector-borne diseases. Her team includes a ��ӽ紫ý undergraduate who occasionally struggled to walk because of pain from Lyme disease.

The disease is spread by blacklegged ticks that become infected after biting mammals or birds carrying the bacteria. The ticks are so small, humans often don’t notice they have been bitten. Symptoms include fever, chills, headache and fatigue, which often are misdiagnosed as a virus or the flu. Even after treatment, Lyme disease patients can face complications including nervous system and heart issues, severe fatigue and arthritic pain.

The disease is most commonly found in Maine to Virginia and in the upper Midwest but is spreading as suburban growth enters wildlife areas. ��ӽ紫ý reports few cases of Lyme disease annually, but travelers who go to endemic areas like New England are at increased risk.

A New Approach to Battle Borrelia

��ӽ紫ý researchers are focused on how B. burgdorferi manages to survive and thrive as it spreads in ticks and mammals to humans.

“The bacteria need to adapt to two different environments, and so we want to know how it does that,” Jewett says. “We’re looking at what the bacteria eat and what it needs to survive. In our lab, we call Borrelia a wimpy pathogen because it can’t make a lot of the nutrients it needs on its own, and so it scavenges what it needs from wherever it is.”

Mollie Jewett and her lab analyze the purification of a novel riboflavin-dependent protein important for Borrelia burgdorferi metabolism.

The first iteration of the NIH grant allowed the scientists to screen all of the bacteria’s genes that might be important for the infection. With the second grant, Jewett targeted three genes that appeared to play a role in spreading the infection from a bite on the skin to other parts of the human body.

“One of these three genes we found is important to the ability of the bacteria to consume riboflavin. We want to target this gene and see if we can starve the bacteria.” — Mollie Jewett, ��ӽ紫ý infectious disease expert

Now they have focused on riboflavin, commonly known as vitamin B2, after discovering that B. burgdorferi salvages the vitamin from each host to sustain itself.

“One of these three genes we found is important to the ability of the bacteria to consume riboflavin,” Jewett says. “We know that riboflavin is a precursor for other cellular activities that are important to the metabolism of the bacteria. Essentially, we want to target this gene and see if we can starve the bacteria.”

If their theory is successful, it could lead to therapies specific to B. burgdorferi that would prevent successful bacterial infection by limiting its riboflavin uptake. An advantage of such potential treatments would be that patients don’t have to take general antibiotics that can also harm the body’s good bacteria and increase risks for antibiotic-resistant bacteria.

The ��ӽ紫ý team is collaborating with Baylor University scientists to trace exactly how riboflavin is used by the bacteria.

Biomedical sciences doctoral student Anna Schulz ’25MS (left) uses genetic approaches to characterize Borrelia burgdorferi genes important for metabolizing vitamin B2. To accomplish this, Schulz and Jewett (right) examine bacterial colonies on solid medium plates.

Students Driving Discovery

Biomedical sciences doctoral student Anna Schulz ’25MS played a key role in pinpointing specific ways the bacteria use riboflavin to generate energy. She served as first author on a recent publication examining these processes, and says she’s looking forward to growing as a researcher in this next phase.

“As a first author, I took more ownership over the experiments and the writing process,” Schulz says. “[Jewett] was really great about letting me lead the project as a student. Borrelia is so unique, and there’s still so much we don’t know, and that’s what keeps me engaged with this research.”

“… I couldn’t treat it until years after I got infected. So, I truly care about finding new treatments for Lyme disease.” — Grace Easterling, ��ӽ紫ý biomedical sciences student

Third-year biomedical sciences undergraduate Grace Easterling says she was drawn to Jewett’s lab because she previously developed Lyme disease and suffered tremendous joint pain. She was determined to find a way to protect others.

“It was something that, because we live in ��ӽ紫ý, wasn’t caught early because it’s not as common,” Easterling says. “I struggled for a long time to get diagnosed, and I couldn’t treat it until years after I got infected. So, I truly care about finding new treatments for Lyme disease and understanding the bacteria.”

Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R01AI099094. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

120 Students Join ��ӽ紫ý to Become Physician Knights

Wendy Sarubbi — Tue, 04 Aug 2026 13:16:11 +0000

Pepi Dostal was inspired to enter medicine by his grandmother, a physician who cared for her village in the Czech Republic. Often paid with eggs or meat from her patients’ farms, she remains the village matriarch even after retirement.

“I saw what she means to her community,” says Dostal, who comes to ��ӽ紫ý from the University of Washington. “And I wanted to do the same thing for my community.”

Dostal was one of 120 new ��ӽ紫ý College of Medicine students who received their white coats Monday in a traditional celebration that welcomes them as partners in healthcare.

Chosen from 5,422 applicants, the 120 new M.D. candidates received their undergraduate degrees from Yale, Vanderbilt, Notre Dame, Duke, Case Western and Emory in addition to ��ӽ紫ý. They include scientists, artists, musicians, athletes, global volunteers and EMTs.

��ӽ紫ý’s M.D. Class of 2030 includes scientists, community volunteers, first responders, athletes and artists.

Monday was the 18th White Coat Ceremony in the history of the medical school, which celebrates its 20th anniversary this year. In his welcome, ��ӽ紫ý President Alexander N. Cartwright described “what began as a bold vision on undeveloped land in Lake Nona has grown into a thriving Academic Health Sciences Campus and a community focused on improving lives.”

And he credited that growth to Deborah German, vice president for health affairs and founding dean, who has announced her transition from both roles. Monday was her last White Coat Ceremony.

“Dr. German helped transform an ambitious vision into the college you join today,” he told students, parents, faculty and staff. “Because of her leadership, hundreds of physicians have begun their careers here, thousands of patients have been served, and new partnerships, discoveries, and opportunities have taken shape across Lake Nona and our state. Dr. German, your remarkable legacy will always hold a special place at ��ӽ紫ý.”

The Good Doctor

For every White Coat Ceremony, German has conducted the first class of medical school called “The Good Doctor – A ��ӽ紫ý Tradition.”

Dean Deborah German conducts the first class of medical school at ��ӽ紫ý — The Good Doctor, a ��ӽ紫ý Tradition.

She asks first-year students to imagine the person they love most in the world is seriously ill with an undiagnosed condition. What are the traits they want to see in the doctor caring for their beloved? As students name attributes, German writes each word on a blackboard that is displayed in the College of Medicine atrium for the entire year.

The class of 2030 suggested 38 traits, including humble, trustworthy, dedicated, knowledgeable, ethical, determined, compassionate, resilient and innovative.

“This is your contract with your faculty, friends, family, community and each other,” German said, pointing to the board. “Always remember, The Good Doctor lives in each of you. With the guidance of the faculty and your own hard work, you will become The Good Doctor.”

Nelson Jones with his family, including both parents who are nurses and inspired him to go into medicine.

Inspired to Care for Others

As a ��ӽ紫ý undergraduate, Nelson Jones earned the Order of Pegasus, the university’s top student honor. Today he is a physician-in-training. Both of his parents are nurses, and he described how their care of others – especially in communities of need – inspired him. So did the opportunities ��ӽ紫ý provides.

“I’m feeling extremely grateful and excited,” he said after receiving his white coat. “This university has built me into the person I am and will continue to build me into the physician I strive to become.”

Vivian Silva-Dallenbach graduated from the University of South ��ӽ紫ý with degrees in biomedical sciences and astronomy. She chose ��ӽ紫ý for medical school because of the college’s new aerospace medicine program. She’s researched how space flight affects the human body.

“Once I saw that ��ӽ紫ý has an aerospace medicine program, I knew it was a match,” she says. “I’m particularly interested in women’s health and how we can provide specialized care for female astronauts.”

Dev Patel, another ��ӽ紫ý alum, says his dreams are inspired by the College of Medicine’s founding dean. “I would like to take a page out of German’s book. She started with almost nothing to work with and she built something amazing here. So as we have such a long road in front of us, I’m hoping to follow in her footsteps and even have a fraction of the impact she did.”

��ӽ紫ý Students, VA Doctor Develop AI Tool to Help Doctors Identify Chronic Pelvic Pain

Eddy Duryea ’13 — Tue, 28 Jul 2026 15:30:57 +0000

For millions of women living with chronic pelvic pain (CPP), finding answers can take far too long.

Studies have shown the condition affects nearly one in four women worldwide and is linked to dozens of potential disorders involving multiple organ systems. Yet many healthcare providers receive only limited training in diagnosing the source of pain, often leaving patients facing years of uncertainty, repeated testing and ineffective treatments before receiving the right diagnosis.

A yearlong collaboration between a ��ӽ紫ý physician-scientist and two biomedical sciences undergraduate students aims to create a better environment for doctors and patients to reach an understanding together. Biomedical sciences students Sarah Gabriela Nieto Chavarro and second-year Juliana Dimetry interned with Georgine Lamvu, a ��ӽ紫ý College of Medicine volunteer professor of obstetrics and gynecology, to transform years of international research into a practical tool to help clinicians evaluate patients more quickly and confidently.

The team is developing an AI-assisted clinical questionnaire application that guides physicians through a patient’s symptoms and identifies which organ systems and conditions should be examined. Rather than replacing a physician’s judgment, the application compiles patient histories quickly to help guide physicians toward making a clearer diagnosis.

From International Research to a Practical Tool

Despite the prevalence of CPP, many healthcare providers lack specialized training in diagnosing the underlying condition because symptoms often overlap with gastrointestinal, urinary, musculoskeletal and reproductive disorders.

“We’re hoping that this can become easy to use and can take a detailed medical history that could take an hour to get through down to just 5 to 10 minutes.” — Georgine Lamvu, volunteer professor and Orlando VA practitioner

“We’re hoping that this can become easy to use and can take a detailed medical history that could take an hour to get through down to just 5 to 10 minutes,” says Lamvu, who practices at the U.S. Department of Veterans Affairs Medical Center in Orlando and directs its gynecological surgery fellowship program and center. “That allows physicians to have a more efficient evaluation and spend more time with the patient.”

The center is a pioneering program designed to address the growing demand for specialized gynecologic care among women veterans. As the number of women veterans using VA healthcare services is expected to increase significantly, this fellowship and center aims to train highly skilled gynecologists to meet their healthcare needs within the VA system and beyond.

As part of that initiative, this project builds upon nearly five years of work led by Lamvu alongside an international coalition of physicians, researchers and patient advocacy groups.

Their research culminated in an international consensus called R U MOVING SOMe, an acronym that categorizes the broad range of symptoms associated with chronic pelvic pain and is the basis of the AI-tool Lamvu and her team developed.

Finding a Definitive Diagnosis

Lamvu says the team translated the clinical research into the logic behind a chatbot-style application that asks fewer than 20 targeted questions. Physicians enter a patient’s symptoms and history into the program, which then suggests the organ systems and conditions most likely responsible for the pain, helping clinicians focus their evaluation.

The team plans to expand the application beyond patient questionnaires by incorporating physical examination findings into the same scoring system. Ultimately, the researchers say they hope it can be used in any practice that serves women, but it may be years away from being realized.

“Physicians just need a way of processing all the information that comes from the patient to narrow it down to a differential diagnosis,” Lamvu says. “Right now, it’s all too common to see healthcare workers panic a little when they hear a patient has chronic pelvic pain because it’s considered a complex condition.”

Biomedical sciences students Sarah Gabriela Nieto Chavarro (left) and Juliana Dimetry (right) with Associate Professor of Medicine Kersten Schroeder (second from right), who was instrumental in facilitating the internship with ��ӽ紫ý College of Medicine Volunteer Professor Georgine Lamvu (second from left) at the Orlando VA.

An Inspiring Internship

The students sifted through years of research and developed the logic for the AI in less than a year. Given the complexity of CPP and the vast amount of data, Lamvu says she is impressed by Dimetry and Nieto Chavarro.

“They learned valuable lessons, like if you see a problem that seems unsolvable to everyone else and that directly and negatively impacts patients, you have the power to do something about it,” she says. “These are experiences not every student gets to have, especially this early on in their life.”

Dimetry says she challenge intrigued her, and that she was drawn to the project for the opportunity to be at the forefront of medicine and emerging technology.

“I think that adapting the field of medicine to AI in ways such as this project is necessary to keep medicine growing and advancing,” she says. “I also saw how impactful this project could be if done successfully, and I wanted to be a part of that and make a difference,”

For Nieto Chavarro, who graduates Summer 2026, the experience showed her how to use technology to help deliver compassionate patient care.

“On a personal level, this experience has taught me to keep going and to never give up,” Nieto Chavarro says. “All of this has ultimately reinforced how essential it is to genuinely listen to patients so they feel safe and understood”

��ӽ紫ý Engineering Students 3D Print Orthopedic Devices to Assist Venezuelan Earthquake Survivors

Marisa Ramiccio ’11 — Fri, 17 Jul 2026 13:30:03 +0000

When two powerful earthquakes struck Venezuela in late June, ��ӽ紫ý engineering students didn’t wait to be asked how they could help. They turned on a 3D printer.

Students in the , with support from the American Association of Venezuelan Engineers (AAVE), are producing 3D-printed orthopedic devices — including splints, neck braces and animal immobilizers — for people and pets injured in the disaster.

The initiative, called Bracing Venezuela, began after BMES leaders contacted Greco Pinzón, president of AAVE. Pinzon’s dad, who has been volunteering in Caracas, Venezuela’s capital, connected the students with physicians on the ground who identified the types of orthopedic devices most urgently needed.

“… before we knew it, we had a campuswide humanitarian project taking shape.”

“From there, everything snowballed,” says Jannah Barakat, a mechanical engineering major and president of BMES. “We started test printing, organizing volunteers, building a print tracker, reaching out to other student organizations, and before we knew it, we had a campuswide humanitarian project taking shape.”

Since launching the effort, BMES has produced more than 350 devices that have been shipped to clinicians in Venezuela. Smaller items, such as finger and wrist splints, take only a few hours to print and are manufactured flat so they can be easily transported. Once they arrive, clinicians soften the material with hot water and mold each device to fit each patient. Larger devices, such as neck braces and animal leg braces, are printed in multiple sizes and can take up to 10 hours to complete. With volunteers printing from across ��ӽ紫ý and beyond, multiple devices can be produced simultaneously.

Bracing Venezuela has received support from Mohsen Rakhshan, an assistant professor in and BMES faculty advisor, who opened his lab’s 3D printer for the project. While many volunteers are engineering students, faculty members, ��ӽ紫ý alumni and 3D-printing hobbyists have also come forward to help.

“One of the coolest things about this project has been watching people from so many different backgrounds come together around one goal,” Barakat says. “Whether you’re printing a brace, packing a box, donating supplies or simply helping us spread the word, every contribution helps get these devices into the hands of the people and animals who need them.”

“I hope this initiative becomes a model for how engineering students can quickly mobilize to respond to humanitarian needs.”

Those interested in joining the initiative don’t need to own a 3D printer. BMES supplies filament to volunteers who have printers, while others can still make an impact by donating materials, connecting the organization with additional volunteers or helping spread the word.

For Barakat, Bracing Venezuela demonstrates what’s possible when engineering students come together for a greater good.

“I hope this initiative becomes a model for how engineering students can quickly mobilize to respond to humanitarian needs,” she says. “Whether it’s supporting communities after natural disasters, helping [less fortunate] populations locally or partnering with organizations in other countries, I’d love to continue using engineering as a way to make healthcare more [widely available] wherever it’s needed.”

To join the Bracing Venezuela initiative, email Jannah.barakat@ucf.edu.

4 ��ӽ紫ý Experts Named 2026 American Academy of Nursing Fellows

Julie Harper ’01 — Tue, 14 Jul 2026 13:37:56 +0000

Four faculty members from ��ӽ紫ý’s College of Nursing have been selected to receive the profession’s most prestigious recognition of fellows of the American Academy of Nursing (FAAN): Jean Davis ’19PhD, Jacqueline LaManna ’13�ʳ��, Kimberly Navarro and Kaitlyn Rechenberg.

��ӽ紫ý has the most inductees among universities in ��ӽ紫ý in the 2026 American Academy of Nursing Class of Fellows, which includes influential healthcare leaders from across the U.S. and around the world. The induction ceremony will be held on Oct. 10, 2026, during the organization’s annual Health Policy Conference in Washington, D.C.

Fellows are selected through a rigorous nomination and review process, and recognized for substantial contributions to improving health outcomes. With the new cohort, the American Academy of Nursing will have more than 3,600 fellows worldwide dedicated to advancing nursing leadership, innovation and science.

The four new inductees, whose collective works have advanced care across the lifespan from pediatrics to older adults, will join 11 fellows of the American Academy of Nursing on faculty at ��ӽ紫ý’s College of Nursing.

Jean Davis ’19PhD

Nursing Associate Professor Jean Davis is advancing public health through her interdisciplinary scholarly work. By working with a collaborative team of public health, psychology, kinesiology and artificial intelligence experts, she has developed and continually improved upon a physical activity habit-forming intervention that tailors cues for movement and optimizes responses to ultimately improve outcomes. This intervention is improving health for veterans and pregnant women, and influencing providers, educators and health systems. Davis is also dedicated to advancing nursing science through active mentorship of ��ӽ紫ý nursing students and early career scholars.

Jacqueline LaManna ’13�ʳ��

For more than three decades, Family Nurse Practitioner and Adult-Gerontology Primary Care Nurse Practitioner Program Director Jacqueline LaManna ’13�ʳ�� has made substantial contributions to advancing diabetes care and self-management education as a provider, educator and researcher. Her scholarly works have been cited more than 250 times and are included in the American Diabetes Association Standards of Care in Diabetes shaping care for pregnant women. In addition, LaManna has helped establish national frameworks for telehealth education for nurse practitioner graduate students that have been accessed more than 4,000 times.

Kimberly Navarro

Lecturer Kimberly Navarro is a certified nurse midwife and board-certified women’s health nurse practitioner who has pioneered community health initiatives to increase healthcare access and improve quality of care for children, adolescents, and pregnant women in the U.S., Guatemala, Haiti, and the Dominican Republic. As program director of the Hispanic serving healthcare professionals graduate certificate at ��ӽ紫ý, Navarro has increased access to the program, strengthened curriculum, and mentored future healthcare professionals. In addition to her faculty appointment Navarro maintains a clinical practice as founder and president of a technology-driven midwifery-led birth center in Orlando.

Kaitlyn Rechenberg

Associate Professor Kaitlyn Rechenberg is advancing standards of behavioral healthcare for children and adolescents living with complex chronic medical conditions through design and implementation of technology-driven interventions. She pioneered the development and validation of the first precision instrument to differentiate diabetes-specific anxiety symptoms from general anxiety symptoms. She also created a mobile health application to deliver tailored mindfulness training to adolescents living with diabetes. Her scholarly work has been cited in seminal position statements by both the American Diabetes Association and International Society for Pediatric and Adolescent Diabetes and has been cited nearly 800 times across 26 countries.

��ӽ紫ý-Led VERA Project Reaches 2 Major Milestones for VR Research

Julie Harper ’01 — Wed, 24 Jun 2026 14:30:23 +0000

After years of research and development led by experts at ��ӽ紫ý in collaboration with researchers from universities across the U.S. and in Europe, the Virtual Experience Research Accelerator (VERA) has reached two major milestones: powering its first full-scale study to address one of virtual reality’s most persistent barriers to adoption and awarding its first use grant to enhance immersive learning and information across industries.

VERA, a platform funded by the U.S. National Science Foundation, is the first, large-scale system for extended reality human subjects research and designed to advance the speed, scale and scope of immersive research. The platform enables immersive researchers to design, deploy, and manage virtual and augmented reality (VR/AR) studies with remote participants therefore significantly improving the quality of the science, while reducing costs, lowering logistical barriers and expanding participant reach.

“No one has built anything like VERA before,” says Pegasus Professor Gregory Welch, lead principal investigator on VERA. “The team was really starting from scratch to create this national platform, integrating AI technologies and establishing policies and procedures that will produce methodologically rigorous behavioral data.”

“We’re excited for VERA to now start to run in an open beta mode and reach these two firsts,” Welch continues.

Cybersickness occurs when symptoms such as nausea, dizziness and discomfort are caused by a mismatch between visual motion in a headset and the user’s physical motion.

Accelerating Understanding of Cybersickness

For its first major large-scale study leveraging remote participants, VERA is helping researchers address one of the most persistent challenges in virtual reality: cybersickness.

Cybersickness occurs when symptoms such as nausea, dizziness and discomfort are caused by a mismatch between visual motion in a headset and the user’s physical motion. Associate Professor of Computer Science Gerd Bruder, who is an affiliate researcher in the Institute of Simulation and Training, is leading the research study in collaboration with other ��ӽ紫ý researchers and external partners.

“Understanding who is susceptible to cybersickness is critical to improving VR accessibility, making VR more comfortable for all users and enabling broader adoption across research, education and industry,” Bruder says.

Early data collection highlights the powerful capabilities of the VERA platform to accelerate VR research at an unprecedented scale.

In just 15 cumulative days, VERA had more than 250 participants complete the full study protocol. In comparison, the original in-lab study collected data from just 30 participants and in traditional VR research settings, studies with hundreds of participants often require several months to complete.

For the study, each participant experiences a controlled VR rollercoaster ride on their own headset and provides sickness ratings at periodic intervals, a pre- and post- exposure questionnaire, an in-VR visual acuity assessment, and continuous head-tracking data. Each session is completed in approximately 30 minutes at home.

“The sectors where VERA can make an impact are expansive, from healthcare to workforce training to accessibility to learning.”

Enrollment is ongoing with a target of 2,000 participants. Preliminary analyses already suggest meaningful individual differences in how quickly and severely participants experience cybersickness.

“VERA was built to study problems like this with a combination of speed, scale and experimental complexity not previously possible,” Welch says. “The sectors where VERA can make an impact are expansive, from healthcare to workforce training to accessibility to learning.”

AdventHealth Endowed Chair in Healthcare Simulation Greg Welch (left) and Associate Professor Gerd Bruder from ��ӽ紫ý’s Institute for Simulation and Training (right) are leading the VERA initiative and first study.

Groundbreaking Immersive Learning Project

For the first project selected in its Use Grant program, VERA is supporting innovative research to study how different immersive technologies engage learners in different ways. The study will help inform how to leverage emerging technologies in education, cultural institutions, public engagement and more.

The grant was awarded to the San José State University School of Information Library Technology Integration Lab in Silicon Valley and New Media Learning, one of the largest providers of virtual reality programming in public libraries.

The project will support a collaborative virtual reality research environment integrated with VERA with participants from across the U.S. in public libraries, universities and other sites.

Researchers will collect behavioral and interaction data including attention patterns, object interaction, navigation pathways, movement, clicks, engagement metrics, and time-on-task, supplemented by surveys and participant feedback. The resulting research environment will serve a scalable prototype for future applications to make immersive learning experiences more accessible to communities worldwide.

A distinguishing feature of the project is the active involvement of San José State University undergraduate and graduate students from the School of Information who will work alongside faculty researchers and technology partners to gain hands-on experience.

“Being selected as the first VERA Use Grant recipient is both an honor and an extraordinary opportunity,” says Anthony S. Chow, professor in the San José State University School of Information and founder of the Library Technology Integration Lab. “Through this collaboration, we hope to generate research that helps libraries, educators, museums and community organizations leverage virtual reality to address some of society’s most important challenges while creating meaningful research opportunities for students.”

“We are excited to welcome San José State University and New Media Learning as the first recipients of a VERA Use Grant,” Welch says. “Their expertise in libraries, immersive learning, public engagement and emerging technologies makes them ideal partners for demonstrating how VERA can accelerate impactful XR research. We believe this collaboration will help establish new models for studying learning, engagement, and information behavior in immersive environments.”

��ӽ紫ý Researcher Studying Probiotics to Fight Acid Reflux, Esophageal Cancer

Eric Eraso — Wed, 03 Jun 2026 13:00:37 +0000

Patients with acid reflux, which occurs when stomach acid pushes up into the esophagus, know the symptoms all too well: heartburn, belching, chest pain and trouble swallowing. In addition to these ailments, acid reflux also increases the risk of esophageal cancer, which has a five-year survival rate of about 22%, according to the American Cancer Society

��ӽ紫ý College of Medicine Associate Professor Claudia Andl, a throat and oral cancer researcher, is investigating how a simple probiotic could treat and prevent both conditions..

��ӽ紫ý College of Medicine Associate Professor Claudia Andl, a throat and oral cancer researcher, is investigating how a simple probiotic could treat and prevent both conditions. The research is funded by a one-year, more than $380,000 grant from the ��ӽ紫ý Department of Health’s ��ӽ紫ý Cancer Innovation Fund.

Probiotics are live microorganisms — usually bacteria or yeasts — that support and strengthen health by increasing the body’s population of healthy cells. Many people take probiotics to improve gut health and digestion. Andl’s research is focused on using a healthy bacteria called Lactobacillus spp. to treat esophageal damage caused by acid reflux and improve the microbial environment in the esophagus to reduce the risk of cancer.

In patients with acid reflux — as well as gastroesophageal reflux disease (GERD), a chronic and more severe form of the digestive condition — stomach acid burns through the lining of the esophagus, causing inflammation and DNA damage to surrounding cells. Over time, those cellular changes can create a condition called Barrett’s esophagus, which increases the risk for esophageal cancer. In addition, when the throat’s bacterial environment becomes dominated by stomach acids and salts, healthy bacteria struggle to survive. Harmful bacteria take their place, causing further cell damage and inflammation that increases cancer risk. Introducing Lactobacillus spp. into disease models has solved both issues.

“We all talk about how important it is to eat yogurt or drink kombucha so that we maintain a healthy bacterial residence in all your organs. And it’s the same in the esophagus.”

“The reintroduction of beneficial bacteria works two-fold,” Andl says. “It restores a normal environment again, but also these Lactobacilli are known to suppress inflammation and repair the DNA damage.”

“We all talk about how important it is to eat yogurt or drink kombucha so that we maintain a healthy bacterial residence in all your organs,” Andl continues. “And it’s the same in the esophagus.”

Early results have shown a reduction in Barrett’s esophagus, and if cancer develops at all, it occurs much later than in models not treated with the probiotic.

Andl says she hopes her research will inform new therapies and provide more information on how to keep the body’s microbial balance healthy to fight disease. She notes this is especially important as data also shows Barett’s esophagus and esophageal cancer are increasing in patients under ages 60-70, the average age for these patient populations.

“We aim to improve outcomes for the large number of reflux patients at risk for cancer,” Andl says. “Playing a role in that would be incredibly rewarding.”

Andl joined ��ӽ紫ý in 2016 after receiving her Ph.D. in cell biology from the University Duisburg-Essen in Germany and conducting postdoctoral research at the University of Pennsylvania.

This research is sponsored by the ��ӽ紫ý Cancer Innovation Fund and the ��ӽ紫ý Department of Health.

��ӽ紫ý Researcher Develops “Smart, Tiny Bubbles” to Treat Cancer and Heart Disease

Wendy Sarubbi — Wed, 20 May 2026 14:21:52 +0000

A cell 500 times thinner than a human hair could heal hearts and kill cancer cells, thanks to a patent-pending technology created by a ��ӽ紫ý researcher and now licensed to a university donor in hopes of getting it to clinical trials.

Dinender Singla, professor and head of the College of Medicine’s Division of Metabolic and Cardiovascular Sciences, developed a system that turns exosomes — vesicles that cells secrete to communicate with one another — into delivery vehicles for medical treatments.

This innovative technology, for which ��ӽ紫ý is seeking patent protection, places therapeutics inside exosomes and coats them with cell-specific markers that direct them to an exact area of the body to deliver the drug.

“I call these smart tiny bubbles,” Singla says. “Millions of people have heart disease, and they take multiple drugs in extremely high doses. But we have no way to be certain these drugs are getting to where they need to go. We need innovative technologies to get treatments exactly where they need to go to cure the problem.”

From left to right: Research Scientist Chandrakala Aluganti Narasimhulu, Jonatas De Mendonca Rolando ’23MS ’26PhD, a ��ӽ紫ý post-doc, ��ӽ紫ý doctoral student Omonzejie Imaralu ’22MS, Dinender Singla and Chakri Toleti.

How the Therapy Works

This discovery is part of Singla’s work to provide therapies to treat and prevent heart disease, including heart damage caused by cancer treatments such as chemotherapy and targeted radiation to the chest. That heart damage seems to be caused by inflammatory factors that treatments use to kill cancer cells. Technology developed by Singla encapsulates anti-inflammatory heart treatments in exosomes and then delivers the drug to the exact area of heart damage.

“They can treat cancer and protect the heart.” — ��ӽ紫ý Professor Dinender Singla

As part of this research, Singla’s team also developed technologies to deliver cancer-killing drugs inside exosomes. They chose triple-negative breast cancer for their research, the deadliest form of the disease, with a 77%–78% five-year survival rate. In the lab, the therapy showed significant promise in killing cancer cells – at much lower doses that are used in chemotherapy – while also protecting the heart. So the exosome therapy could help cancer patients without the severe side effects of chemotherapy.

“These therapies can work hand-in-hand,” Singla said. “They can treat cancer and protect the heart.”

Financial Investment is Key for Drug Development

The next step will be manufacturing the therapy for clinical use and advancing into FDA clinical trials for heart disease and cancer treatment. To help accelerate that path, Singla partnered with Orlando investor and ��ӽ紫ý donor Chakri Toleti, a healthcare technology entrepreneur focused on building category-defining businesses through AI and agentic platforms, biomedical innovation and ambient intelligence including most recently care.ai, which was acquired by Stryker in 2024.

Through his innovation fund, TCapital, Toleti backs transformative technologies designed to improve healthcare delivery and reduce human suffering at scale. Together, Singla and Toleti invested in and formed Exomic to fund continued research, clinical development, and commercialization of the technology.

“This was an opportunity to do something truly innovative in cancer and cardiovascular treatment.” — Chakri Toleti, ��ӽ紫ý donor

Toleti says his passion for advancing cancer research is deeply personal after losing his father to the disease.

“This was an opportunity to do something truly innovative in cancer and cardiovascular treatment,” he says. “Dr. Singla’s work represents a fundamental shift toward new biomedical platforms not only in how targeted therapies are delivered in the human body, but in how we think about treatment and healing itself.”

Such public-private partnerships are one of the goals of , which drives innovation, enterprise, and collaboration across disciplines.

“Dr. Singla’s groundbreaking exosome delivery system perfectly exemplifies how university innovation translates into significant, life-saving benefits for society,” says Winston V. Schoenfeld, vice president for research and innovation. “As demonstrated by the creation of Exomic, industry partnership is essential for driving such pioneering technologies towards successful translation and real-world clinical use.”

The effort is also providing exciting learning opportunities for College of Medicine graduate students. Jonatas De Mendonca Rolando ’23MS ’26PhD earned his Ph.D. in biomedical sciences earlier this month. He is staying at ��ӽ紫ý as a post-doctoral researcher to continue creating the exosome therapy.

He helped develop protocols and procedures for the delicate technology and saw its impact in the lab. He’s excited to have a financial supporter who can help take the therapy from lab to, he hopes, patients.

“It’s been amazing to part of a high-tech project and see leadership in science,” he says. “I am very excited for my future.”

Researcher Background

Singla is the AdventHealth Endowed Chair of Cardiovascular Sciences at the Burnett School of Biomedical Sciences and is a faculty fellow with the ��ӽ紫ý Office of Research. He earned his bachelor’s and master’s degrees from Punjabi University, Patiala, India, and his Ph.D. from the Post Graduate Institute of Medical Education and Research, Chandigarh, India. He has published more than 100 peer-reviewed papers and has continually been funded by the American Heart Association and/or the National Institutes of Health since 2004.

About TCapital

TCapital is an AI, Frontier Tech and Life Sciences innovation fund investing in category-defining platforms and infrastructure. Founded by healthcare technology entrepreneur Chakri Toleti, T-Capital invests in companies shaping the future of treatment, care, and biomedical innovation. For more information, visit TCapital.com.

The Next Elite Sports Physical Therapists

Robert Stephens — Wed, 06 May 2026 13:30:23 +0000

Alvaro Zapata and Tsianna Barnwell have never feared the highest level of competition. They crave it. Growing up, soccer, track and football lit internal fires that burn to this day, which helps explain how they made it into an exclusive cohort: the ��ӽ紫ý and Orlando Health sports physical therapy residency. With just two residents accepted each year, Zapata and Barnwell made the cut from a list of 30 high-performing applicants, meaning they’re as elite as the athletes they work with.

“The residency accelerates clinical reasoning by three to five years, making [residents] more competitive candidates for the best jobs.” — Meredith Chaput, research coordinator and liaison for the ��ӽ紫ý and Orlando Health sports physical therapy residency program

“We look for people who thrive on rigor,” says Assistant Professor of Physical Therapy Meredith Chaput, the residency’s research coordinator and liaison. The payoff is priceless. “The residency accelerates clinical reasoning by three to five years, making them more competitive candidates for the best jobs.”

Chaput’s sport-specific expertise, along with that of four of her colleagues in the ��ӽ紫ý Division of Physical Therapy who serve as didactic and clinical mentors, is an instant draw to the program. So, too, are ��ӽ紫ý’s research labs, partnerships and the opportunity to teach students in the ��ӽ紫ý doctor of physical therapy program.

The residents are equally drawn to the opportunity to advance their skills alongside a seasoned clinical team at Orlando Health. They take on a caseload of sports and orthopedic patients, providing specialized care ranging from post-surgical rehabilitation to elite-level performance optimization, tapping into advanced rehabilitation technology to improve athlete recovery. Nearly 2 million people every year suffer sports-related injuries and receive treatment in emergency departments, according to the U.S. Department of Health and Human Services.

With all of this in place, professionals are being prepared, two at a time, through a specialized 12-month program, to join the select group of 169 board-certified sports clinical specialist physical therapists in ��ӽ紫ý. It’s a coveted residency and one designed to develop healthcare providers to better aid athletes of all levels. Central ��ӽ紫ý is a premier sports destination, featuring a mix of professional franchises, elite collegiate athletics, large high schools and massive amateur complexes.

“When we started this program in 2020, our mission initially aimed to strengthen the rehabilitation services provided to the local sports-based community within Central ��ӽ紫ý by producing highly trained and skilled sports physical therapists,” says Philip Agostinelli, residency program coordinator and rehab clinical operations manager with Orlando Health Sports Medicine and Rehab Center. “Now, currently, in our sixth cohort of residents, that mission evolved to encompass the needs of athletes on a national scale, with multiple past graduates working in professional or semi-professional sports across the country.”

Since entering the ��ӽ紫ý and Orlando Health Sports Physical Therapy program, Alvaro Zapata has accessed the inner circles of Orlando’s two professional soccer teams.

The Tireless Protege: Alvaro Zapata

Long days do not faze Alvaro Zapata, even as they turn into 60-hour weeks. To him, they’re part of the allure of the residency program.

“I ask myself, ‘When would I have this kind of opportunity again?’ and the answer is never,” Zapata says. “The program opens doors that would otherwise not be open.”

“I’m gaining all the knowledge I could possibly need to eventually be at the top of my profession.” — Alvaro Zapata

Since entering the program last August, Zapata has stretched his aptitude alongside clinicians at Orlando Health and Jewett Orthopedic. He’s worked with athletes in high schools and at ��ӽ紫ý and accessed the inner circles of Orlando’s two professional soccer teams.

As Zapata puts it, “I’m gaining all the knowledge I could possibly need to eventually be at the top of my profession.”

Zapata was poised to climb the ladder with his Doctor of Physical Therapy from Boston University when he heard about Chaput heading up the residency program at ��ӽ紫ý. He knew of her published research and presentations to global audiences.

“She’s a big reason I wanted this residency so badly,” Zapata says.

At the 2026 Isokinetic Conference, Alvaro Zapata presented progress on a rehab model he co-developed, examining how ACL surgery can disrupt instinctive movement and coordination.

Here, he has had the opportunity to collaborate with Chaput and progress research on the “visual-cognitive control-to-chaos continuum” in rehab, a model for which Chaput is one of the original creators. After ACL reconstruction surgery, patients often develop inhibitions within the brain that limit the coordination of knee movement. Instead of movement in competition being instinctive, athletes are often consciously aware of deficiencies that were once automatic.

“If you can’t trust your knee, then you can’t get back to the top of your game,” Zapata says. “Rehab is typically done in a controlled setting. The real sports environment is chaotic. We’re finding ways to challenge people the day after surgery, so inhibitions don’t set in.”

This means “visual-cognitive” challenges are added to rehab in the very early stages. For example, the physical therapists might have the patient look for colored lights on a screen. Red means squeeze the right leg. Blue means squeeze the left leg. Yellow means squeeze both.

The visual-cognitive control-to-chaos continuum calls for therapists to gradually make exercises more complex for the patient, from simple, controlled movements to more unpredictable, game-like situations. The goal is to better prepare patients to safely return to sports by training both the body and the brain.

“We want athletes to react instead of thinking first,” Zapata says. “It could be a game changer.”

Tsianna Barnwell is building her skill set through hands-on work with the Orlando Pride.

The Team Player: Tsianna Barnwell

At noon on a Monday, Tsianna Barnwell leaves Jewett Orthopedic Clinic, where she’s been broadening her skills since 7 a.m. She’ll now drive to a local high school to work with athletes across a range of sports. Barnwell thrives in the residency program because no two days are the same. She might work with the Orlando Pride or Orlando City, provide expertise for USA Track or binge on insights at Orlando Health.

Some people call the program challenging. Barnwell calls it “incredible.”

“I’m getting the best of all worlds,” she says. She even immerses herself in the world of Orlando Ballet, calling it “another unique experience to add to my toolbox.”

In the Cognition, Neuroplasticity and Sarcopenia Lab, Tsianna Barnwell (left), assisted by Alvaro Zapata (right), studies differences in hamstring muscles between men and women to inform rehabilitation, recovery and injury prevention.

Barnwell takes her toolbox into the Cognition, Neuroplasticity and Sarcopenia Lab, where she and Chaput are advancing research, which they recently presented in Athens, Greece, at the Isokinetic Conference. It started with a question Barnwell had from her days as a Division I soccer player: Why are female athletes two to six times more likely to suffer knee injuries than men? Through her sports residency, she’s discovered that females are more likely to be weaker in their hamstring muscles. Studying these anatomical and physiological differences can inform impactful changes in rehab, recovery and injury prevention, she notes.

“With this residency under my belt, my opportunities will be almost endless.” — Tsianna Barnwell

Barnwell knows firsthand what it’s like to suffer a torn ACL. She’s also known “the team” as her home away from home since leaving Qatar as an 18-year-old to study and play soccer at St. Bonaventure University. Ultimately, she wants to be part of a team again, perhaps as the director of rehabilitation for a professional women’s soccer team. That’s her preference, but when the residency ends, she’ll be prepared to work with any team — even a ballet company, Cirque du Soleil or the rehab team at Orlando Health.

“I’m fortunate to gain such a breadth of knowledge,” Barnwell says. “With this residency under my belt, my opportunities will be almost endless.”

Jeremy Wydra ’18 ’22DPT was among the presenters at the 2026 Isokinetic Conference in Athens, Greece.

The Empowered Graduate: Jeremy Wydra ’18 ’22DPT

Jeremy Wydra ’18 ’22DPT is where Zapata and Barnwell will soon be: residency complete, now pursuing a path to find more effective ways to help athletes and performers recover and raise the bar.

“That’s the great outcome for me: variety,” says Wydra, who finished the residency program in 2024 and is now practicing clinically, and working toward his doctorate in kinesiology at ��ӽ紫ý, where he is collecting data on the recovery and return to performance after ACL reconstruction.

Wydra worked his way through ��ӽ紫ý, first envisioning a career in mechanical engineering and ultimately earning a bachelor’s in health sciences. Along the way, he decided he wanted a people-facing profession and shadowed at a clinic, where he noticed physical therapists conversing with patients throughout treatment sessions, often for more than an hour. He saw it as personalized healthcare that he could optimize with physics and innovation.

Jeremy Wydra ’18 ’22DPT (right) works with a student-athlete in a training facility.

After finishing his doctorate in physical therapy at ��ӽ紫ý, Wydra landed in a dream situation in Maryland, practicing as both a strength and conditioning coach and a physical therapist within sports performance centers. It begs the question: Why return for the residency?

“I wanted to work with mentors who would push me to be better,” says Wydra.

Unlike Zapata and Barnwell, Wydra had little soccer experience. Gaining it became part of the push he desired.

“… the value of the residency for me: having access to such diversified people and environments.” — Jeremy Wydra ’18 ’22DPT

“During my second week in the residency, I stepped into the Orlando City Academy training room to work with high-level athletes,” he says. “I also helped on the sidelines and talked with the medical staff about team-centered communication with coaches and players. That was the value of the residency for me: having access to such diversified people and environments.”

Wydra sees himself taking full advantage of the variety still in front of him, perhaps as a physical therapist and sports scientist, reforming best practices and helping others be their best.

“That’s what my mentors in the residency have done for me: made me a better person and professional,” he says. “I wouldn’t trade those 12 months for the world.”

��ӽ紫ý, Orlando Health Co-Locate to Accelerate Healthcare Innovation

Robyn Lorfink — Thu, 30 Apr 2026 14:15:27 +0000

Yesterday, Orlando Health celebrated the opening of Orlando Health Strategic Innovations located within SPRK, ��ӽ紫ý’s innovation building, expanding the health system’s presence at the center of ��ӽ紫ý’s main campus.

Designed to accelerate innovation, the Orlando Health Strategic Innovations group connects real clinical and operational challenges with student and academic talent, creating a healthcare environment where ideas are tested, informed by feedback, and continually improved. The space serves as an extension of the system’s downtown headquarters and is jointly funded by Orlando Health Ventures and the Orlando Health Innovation teams.

Orlando Health’s presence within SPRK aligns with ��ӽ紫ý’s broader co-location strategy, which brings industry partners onto campus to catalyze innovation through proximity. The approach emphasizes shared space, shared challenges and shared outcomes to accelerate problem-solving, support experiential learning and speed the translation of ideas into practice.

The co-location marks the latest milestone in Orlando Health’s long-standing partnership with ��ӽ紫ý.

“By working side by side at SPRK, we are accelerating innovation and moving real-world healthcare solutions more quickly into the communities we serve.” — Alexander N. Cartwright, ��ӽ紫ý president

The Orlando Health Jewett Orthopedic Institute provides comprehensive, year-round care for ��ӽ紫ý student-athletes, including on-field coverage, primary care sports medicine, and specialized imaging. As a Pegasus Partner, Orlando Health pledged $5 million toward the , which supports nursing internships, scholarships, and hiring, helping to address the state’s nursing shortage. In addition, Orlando Health and ��ӽ紫ý collaborate on advanced technology projects — such as the AI for Medical Surgery system — jointly offer specialized residency programs and collaborate in many additional ways.

“Orlando Health has been an exceptional partner, demonstrating what is possible when industry and academia come together with shared purpose. This next phase of co-location builds on that foundation,” says ��ӽ紫ý President Alexander N. Cartwright. “By working side by side at SPRK, we are accelerating innovation and moving real-world healthcare solutions more quickly into the communities we serve.”

Healthcare Innovation at the Center of Campus

Located in approximately 2,649 square feet within SPRK, the Strategic Innovations group was intentionally placed, here, to foster continuous collaboration with faculty and students across disciplines.

This co-location enables a new operating model. Orlando Health brings real health system challenges directly into the academic environment, and interdisciplinary teams of students, faculty, and Orlando Health innovators rapidly design, test, and refine solutions.

Early collaboration has already begun to generate impact in areas such as cancer research, digital health, creation of AI models and various orthopedic innovations.

“The opening of an Orlando Health Strategic Innovations space at ��ӽ紫ý represents our shared commitment to advancing healthcare delivery through bold new ideas,” says Jamal Hakim, M.D., chief physician officer, Orlando Health. “Through this partnership, we are creating a collaborative environment where clinicians, researchers, students and industry leaders can generate real-world solutions and drive innovations that will shape the future of how we care for patients.”

Built to Go For Launch

The latest milestone in , this co-location represents ��ӽ紫ý’s deep commitment to the ecosystem of support powering our vision for the future.

Through a collective effort — combining philanthropy and transformational giving with corporate partnerships, research commercialization and other revenue-generating endeavors — ��ӽ紫ý is charting a bold new path forward and building a future the world has only begun to imagine.

“This co-location with Orlando Health exemplifies the kind of partnership that powers Go for Launch, bringing industry and academia together to create real-world impact,” says Rod Grabowski, ��ӽ紫ý vice president for Advancement and Partnership, and CEO of the ��ӽ紫ý Foundation. “By aligning visionary partners with ��ӽ紫ý’s innovation ecosystem, we are accelerating discovery, expanding opportunity and advancing solutions that improve lives.”

Healthcare Archives | University of Central ���ӽ紫ý News

���ӽ紫ý Scientist to Explore Precise Treatment Targeting Weak Spots in Lyme Disease Bacteria