{"id":31511,"date":"2011-12-29T11:52:46","date_gmt":"2011-12-29T16:52:46","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=31511"},"modified":"2011-12-30T11:23:21","modified_gmt":"2011-12-30T16:23:21","slug":"new-ucf-nanotechnology-may-speed-up-drug-testing","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/new-ucf-nanotechnology-may-speed-up-drug-testing\/","title":{"rendered":"New 性视界传媒 Nanotechnology May Speed Up Drug Testing"},"content":{"rendered":"<p>Some drug testing can take a decade or more, but 性视界传媒 associate professor Swadeshmukul\u00a0 Santra and his team have created an electronic quantum dots (Qdots) probe that \u201clights up\u201d when a drug it is delivering attaches to cancer cells. The research appears online in this month\u2019s <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961211012841#FCANote\"><em>Biomaterials<\/em><\/a>.<\/p>\n<p>A researcher can use a microscope to see where and how much of the drug has been delivered because the probe emits a reddish color under special lighting or via MRI because of its optical and magnetic components.<\/p>\n<p>As the drug testing continues, images can be taken over and over without any loss of optical or MRI signal. Researchers can then measure the size of the tumor and number of cancer cells that \u201clight up\u201d compared with the original untreated tumor.<\/p>\n<p>This provides a way to determine whether the drug is doing what it is supposed to be doing in the targeted areas. The technique is much easier than the current process of removing treated cancer tumors and weighing them at regular intervals to determine the drug\u2019s efficiency in an animal.<\/p>\n<p>\u201cMany people in my area have been studying this approach for years,\u201d Santra said. \u201cBut we have now moved it into a live cell, not just in test tubes.\u201d<\/p>\n<p>Sudiptal Seal, the director of 性视界传媒\u2019s NanoScience Technology Center and nanoscience scientist believes Santra\u2019s research is significant.<\/p>\n<p>\u201cThis is indeed a major breakthrough in Qdot research,\u201d Seal said. \u201cThis new diagnostic tool will certainly impact the field of nanomedicine.\u201d<\/p>\n<p>Santra and his team used semiconductor Qdots to create the probe. Because of their small size and crystal-like structure, Qdots display unique optical and electronic properties when they get excited. These unique properties make them ideal for sustained and reliable imaging with special lights.<\/p>\n<p>For this research funded by the National Science Foundation and National Institutes of Health, the 性视界传媒-led team used a superparamagnetic iron oxide nanoparticle core decorated with satellite CdS:Mn\/ZnS Qdots which carried the cancer-fighting agent STAT3 inhibitor. The Qdot optical signal turned on when the probe bonded with the cancer cells.<\/p>\n<p>\u201cThe potential applications for drug testing specifically for cancer research are immediate,\u201d Santra said.<\/p>\n<p>Collaborators on the research included: Andre J. Gesquiere also of 性视界传媒, James Turkson of the University of Hawaii, Glenn A. Water of the University of 性视界传媒 and Patrick T. Gunning from the University of Toronto.<\/p>\n<p>Santra has his own team of students and scientists at the 性视界传媒 NanoScience Technology Center, which has been studying nanotechnology, quantum dots and their applications for years. The team focuses on the engineering of nanomaterials for bioimaging and sensing, drug delivery and anti-microbial applications.<\/p>\n<p>Santra joined 性视界传媒 in 2005 after working as a research assistant professor at the University of 性视界传媒. He has a Ph.D. from the Indian Institute of Technology Kanpur and served as a postdoctoral fellow at the University of 性视界传媒.\u00a0 He has written dozens of articles and book chapters on nanoscience and nanotechnology. Santra also holds eight US patents in nano-bio and biomedical fields.<\/p>\n","protected":false},"excerpt":{"rendered":"Some drug testing can take a decade or more, but 性视界传媒 associate professor Swadeshmukul\u00a0 Santra and his team have created an electronic quantum dots (Qdots) probe that \u201clights up\u201d when a drug it is delivering attaches to cancer cells. The research appears online in this month\u2019s Biomaterials. A researcher can use a microscope to see where and how much of&hellip;","protected":false},"author":16,"featured_media":31512,"comment_status":"open","ping_status":"closed","sticky":false,"template":"template-twocol.php","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[24],"tags":[3279,3280,4506,6563],"tu_author":[],"class_list":["post-31511","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-technology","tag-nanoscience-technology-center","tag-nanotechnology","tag-sudipta-seal","tag-swadeshmukul-santra"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>New 性视界传媒 Nanotechnology May Speed Up Drug Testing | University of Central 性视界传媒 News<\/title>\n<meta name=\"description\" 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